Mouse CCR9 β-Arrestin CHO
CBP71620
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產(chǎn)品描述
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| I. Background | |
| 趨化因子受體 9 (chemokine receptor 9,CCR9),屬于β趨化因子受體家族。它由轉(zhuǎn) 錄本 A(369 個(gè)氨基酸,42 kDa)和 B(357 個(gè)氨基酸,40.8 kDa)組成。CCR9 主要分布 在未成熟的 T 淋巴細(xì)胞和腸細(xì)胞表面,結(jié)合其特異性配體,在 T 淋巴細(xì)胞發(fā)育和組織特異 性歸巢中發(fā)揮作用。研究證明,CCR9 在多種癌癥中高表達(dá),是一種潛在的腫瘤生物標(biāo)志 物,可用于診斷和治療。 CCR9 被其特異性配體 CCL25 激活后,可以與許多信號(hào)通路相互作用,特別是與腫瘤 化療耐藥和轉(zhuǎn)移有關(guān)的信號(hào)通路。 |
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| II. Description | |
| Mouse CCR9 β-Arrestin CHO 報(bào)告基因藥靶模型很好的模擬了 CCR9 的信號(hào)轉(zhuǎn)導(dǎo)過(guò)程。 | |
| III. Introduction | |
| Expressed gene: |
Mouse CCR9 |
| Host Cell: |
CHO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5 μg/ml Puromycin+5 μg/ml Blasticidin |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for Mouse CCR9 Receptor |
| Assay Format: | β-Arrestin |
| IV. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
V. Representative Data![]() Figure 1. Recombinant Mouse CCR9 β-Arrestin CHO stably expressing CCR9. ![]() Figure 2. Dose Response of Mouse CCL25 in Mouse CCR9 β-Arrestin CHO(C89). |
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