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FLT3-ITD [Y842C]/BaF3

CBP73100

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I. Introduction
Cell Line Name: FLT3-ITD [Y842C]/BaF3
Host Cell: Ba/F3
Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Freeze Medium: 90% FBS+10% DMSO
Complete Culture Medium: RPMI-1640+10%FBS
Mycoplasma Status: Negative
 
II. Background

FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385).

 
III. Representative Data

1.FLT3-ITD [Y842C]/BaF3

2. Anti-proliferation assay

 

Figure 2. Anti-proliferation assay of two reference compounds on the FLT3-ITD [Y842C]/BaF3 Stable Cell Line.

 

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藥靶模型聯(lián)系方式: 華東銷(xiāo)售經(jīng)理(上海):18240630236 華東銷(xiāo)售經(jīng)理(上海、江蘇、安徽):15715191010 華北銷(xiāo)售經(jīng)理:18628311252 華南銷(xiāo)售經(jīng)理:13823536064 華中&華西銷(xiāo)售經(jīng)理:18071545918 華中&西南銷(xiāo)售經(jīng)理:13871580511 全國(guó)銷(xiāo)售經(jīng)理:13816461235
診斷標(biāo)準(zhǔn)品聯(lián)系方式: 華東銷(xiāo)售經(jīng)理:15000320447 華北銷(xiāo)售經(jīng)理:18628311252 華南銷(xiāo)售經(jīng)理:13823536064 華中&華西銷(xiāo)售經(jīng)理:18071545918 華中&西南銷(xiāo)售經(jīng)理:13871580511 全國(guó)銷(xiāo)售經(jīng)理:13816461235

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