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tTMB-P8(27.15) Reference Standard

CBP80001-8

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I. Background

Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials.

 

Sample ID

Cat.No.

Background

Assay

Comments

DC198N0165
CBP80001-8N B lymphoblast, Female 500x WES

 Same individual

DC198N0164

CBP80001-8T

Ductal breast carcinoma, Female

500x WES

IDT xGenExome Research Panel v1.0捕獲,Target Region 39M, Probe Region 51M, CDS Region 33.52M;
HiSeq X-TEN,af選擇0.02 cut off,再過濾。
DC198N0164 is 100% Tumor sample.

 

 

Cut off =2%

Cut off =3%

Cut off =4%

Cut off =5%

Mutation Number

910

840

766

685

TMB value

27.15

25.06

22.85

20.44 

 

計(jì)算數(shù)據(jù)下載:DC198N0164.tmb

 
 
 
 

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