CYP2D6*2 Reference Standard
CBPA0045
詢 價(jià)
索取COA
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫(kù)
| Introduction | |||||
| Format | Genomic DNA | ||||
| Description | CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been associated with risks of various cancers (PMID: 22994728, PMID: 16550168) and may alter the metabolism of tamoxifen in breast cancer patients. | ||||
| Technical Data | |||||
| Gene | CYP2D6*2 | ||||
| Mutation Type 1 | AA Change: p.R296C | ||||
| DNA Change: NM_000106.6:c.886C>T | |||||
| Chr position (GRCh38): NC_000022.11:g.42127941G>A | |||||
| Mutation Type 2 | AA Change: p.S486T | ||||
| DNA Change: NM_000106.6:c.1457G>C | |||||
| Chr position (GRCh38):NC_000022.11:g.42126611C>G | |||||
| Allelic Frequency | 50% | ||||
| Zygosity | Heterozygous | ||||
| Product Information | |||||
| Intended Use | Research Use Only | ||||
| Unit Size | 1ug | ||||
| Concentration | Download for COA | ||||
| Purofication | Download for COA | ||||
| DNA electrophoresis | Download for COA | ||||
| Sanger sequencing |
Figure 1. CYP2D6*2 Reference Standard p.R296C
Figure 2. CYP2D6*2 Reference Standard p.S486T |
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| Storage | 2-8°C | ||||
| Expiry | 36 months from the date of manufacture | ||||
