CXCR5/CHO
CBP71370
詢 價
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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
| I. Background | |
| 趨化因子受體是 G 蛋白偶聯(lián)的七次跨膜細胞表面受體,其配體與其結(jié)合具有高親合力。迄今為止,至少有 20 種趨化因子受體已被確認,這些受體也可以分為四種亞型:CXC 趨化因子受體(CXCRs), CC 趨化因子受體(CCRs), XCR 和 CX3CR。 CXCR5(C-X-C 趨化因子受體 5 型)是特異性結(jié)合趨化因子 CXCL13 的 GPCR,核心功能為介導 B 細胞、濾泡輔助 T 細胞(Tfh)及濾泡樹突細胞向次級淋巴器官(淋巴結(jié)/脾 臟濾泡)的定向遷移與定位,驅(qū)動生發(fā)中心形成、抗體親和成熟及黏膜免疫應答(如腸道 派氏集結(jié)聚);其信號通過 Gi 蛋白-PI3K/Rac 通路活化細胞骨架蛋白,建立免疫微環(huán)境空間秩序。 |
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| II. Description | |
CXCR5 CHO 藥靶模型很好的模擬了體內(nèi) CXCR5 的信號轉(zhuǎn)導過程,原理見下圖所示。 ![]() Figure 1. CXCR5 CHO 細胞模型原理圖 |
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| III. Introduction | |
| Expressed gene: |
CXCR5 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+5ug/ml Puromycin |
| Mycoplasma Status: | Negative |
| Storage: | Liquid nitrogen immediately upon delivery |
| Application(s): |
Functional assay for CXCR5 |
| Transducer: | Gi |
| IV. Description of Host Cell Line | |
| Organism: | Hamster |
| Tissue: | Ovary |
| Morphology: | Epithelial |
| Growth Properties: | Adherent |
| V. Representative Data | |
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Figure 2. Recombinant CXCR5/CHO cell line expressing CXCR5. |
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Figure 3. HTRF cAMP Assay with CXCR5 CHO(C5). |
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